Usp 32 standard2/15/2023 ![]() Mechanistically, USP32 silencing caused a decrease in the expression of SMAD2, which resulted in the inhibitory effects of GC cells on growth, motility, and chemoresistance to cisplatin. Further analyses showed that high expression of USP32 was closely related with high T-staging and poor outcomes of GC patients. Importantly, results from immunohistochemical staining in a tissue microarray revealed that USP32 was upregulated in GC tissues compared with paracancerous tissues. In the present study, we reported that knockdown or depletion of USP32 significantly inhibited GC cell proliferation and migration in vitro and in vivo, indicating that USP32 functions as an oncogene in GC. However, its biological functions and clinical significance in gastric cancer (GC) remain unclear. USP32, a member of the ubiquitin-specific proteases family, has been implicated in the development of breast cancer and small lung cancer. ![]()
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